Article Directory Video Tape ProblemsDirectory Free Contents

Human organism is a unique phenomenon. After the long and complicated process of evolution our organisms are able of coping with great difference of temperatures, heal dangerous wounds and knit fractured bones. They are able of surviving many infections, fixing different injuries and restoring after hard nervous stress and strain. If we fail to avoid health troubles pain is the first price you have to pay.

Every single burn, bruise and scratch in our life is entailed with pain. This awful throbbing sensation is the most hated feeling in the world, surprisingly we would not be able to survive without pain. Believe it or not but it is pain that makes us smart and more attentive to the needs of our body. It is the best keeper of our health that is always there for you - tireless and alert. You will not be able to forget about your injury and hurt yourself even if you fall asleep. You will have no opportunity of ignoring your bad tooth until things turn radically wrong because pain won’t let you to! Absence of physical pain would have made us too careless to pay the slightest attention to our health and well-being. Do you still hate pain, the best and the most reliable friend of yours?

But sometimes pain becomes entirely excruciating and persons think it more desirable to pass away than to tolerate an awful ordeal like that. No wonder the humanity kept looking for medicines able of relieving pain. Today we have the power of chemistry and contemporary pharmacology in addition to natural stuffs to create safe and highly effective ways of overcoming pain.

Analgesic medications today are different and large in number. Some of them are extracts of natural ingredients, others are purely chemical substances; there are also various mixtures of the two. Tramadol is one of them. It is a centrally-acting analgesic used in managing moderate to moderately severe pain. This medications is relatively new - it was produced German pharmaceutical company Grünenthal GmbH in the late 1970s. It was a successful synthetic analog of Codeine, the phenanthrene alkaloid and opioid. Just like Codeine, Tramadol proved to be a full-fledged prodrug, too. Unlike Codeine, converted in our organisms to Morphine, Tramadol is metabolized into M-1. Both substances affect the human opiate receptors or μ1 and μ2 receptors. Tramadol is also known for releasing serotonin in human brain and inhibiting the effect of norepinephrine.

Tramadol can provoke euphoria and respiratory depression, because it is a very addictive opioid having serotonergic and noradrenergic effects and working on the μ-opioid receptors exclusively. This unique characteristic feature of Tramadol and its major metabolites makes this med stand alone among other compounds of the opioid drug class - even Morphine does not possess this extent of receptor subtype selectivity!

As we have told you before Tramadol, just like codeine and other opioids, are normally used to cure moderate to moderately severe painful states as well as the most types of neuralgia. When physicians first saw Tramadol action on the noradrenergic and serotonergic systems of patients they believed the drug could be effective for overcoming the symptoms of depression, anxiety and phobias. However the addictiveness of Tramadol kept it from becoming a mainstream tranquilizer. Today Tramadol is sometimes used these purposes but only when other therapies failed. In this case rigid Tramadol dosage control and regular psychiatrist consultations are necessary!

Tramadol ways are not that easy. Being highly effective, the med can have side effects and from strong addiction, that is why there are always personalities who are ready to misuse. The German company Grünenthal GmbH has been repeatedly charged of producing Tramadol, which is very addictive and can cause severe side effects, while the company is not informative enough and states that the medicine showed little abuse liability in preliminary tests. Later in May 2009, the US FDA created a warning letter to the company of Johnson & Johnson, because they promoted Tramadol overstating the efficacy of the drug, and minimizing the possible serious risks. The 2010 Physicians Desk Reference contains a number of manufacturer warnings, which were not present before. They contained strict warnings about:

- the addictive potential of Tramadol,
- the high risk of difficulty breathing,
- a new extended list of side effects including more severe cases,
- a fact that Tramadol should not to be used instead of opiate medications for addicts,
- a notice that Tramadol should not to be used to withdraw addict patients from opiate drugs,
- a warning that Tramadol should not to be used to manage long-term opiate addiction.

Tramadol is available as:

- solutions for both intravenous and intramuscular injections. The injection solutions are used in patient-controlled analgesia cases either as the sole agent or with another opioid agent such as Morphine;
- capsules which are believed to protect your stomach better;
- tablets (regular, extended release, chewable etc);
- suppositories for rectal administration;
- powders for compounding;
- liquids both with and without alcohol for oral and sub-lingual administration.

As a rule you can get cheapest Tramadol online as the tramadol hydrochloride for oral administration.

The universal dosage of Tramadol is 50 mg generic tablets made by several manufacturers. Effective pain-killing compounds with APAP such as Paracetamol and Acetaminophen are also commonly available as Ultracet medication. In this case the tablet contains smaller dose of Tramadol (37.5 mg) and larger dose of APAP (325 mg).

Tramadol is a medication with special unpleasant taste which is mildly bitter. All the same, it is less bitter than other opioids such as Morphine and Codeine. The biggest safe dosage of Tramadol for oral administration is 400 mg a day and 600 mg of Tramadol for parenteral administration.

To be on the safe sade you should never reach the maximum dosage of Tramadol! So, Ultracet tablets with 37.5 mg of tramadol and 325 mg of APAP in it is capped at 8 tablets a day, that is 300 mg of Tramadol. Ultram ER tablets containing Tramadol are available in 100, 200, and 300 mg/day doses, too.

It is absolutely ruinous to take Tramadol if:

- you are over 75 years old or under 18 years old;
- you have severely reduced renal (kidney) or hepatic (liver) functions;
- you take other opioids such as oxycodone, methadone, fentanyl, morphine.

Please, make an appointment with your physician before getting Tramadol online without a rx - he or she will tell you about the safest way of applying Tramadol or will explain you why you should not start this med at all.

It is wrong to say that MDs and investigators know everything about Tramadol. This unique med is still being clinically tested. So, Tramadol proves to be effective and safe in resisting diabetic neuropathy, post-herpetic neuralgia, fibromyalgia, restless leg syndrome, Anti-Depressant withdrawal aid (especially for Venlafaxine or Effexor), migraine headache, obsessive-compulsive disorder and premature ejaculation.

You will be surprised to decipher that Tramadol is one of the most trusted and efficient drugs available to veterinarians for treating animals in pain. So, Tramadol may be used to fight back post-operative, injury-related, and chronic pain in dogs, cats and other mammals. It is less ruinous than some non-steroidal anti-inflammatory substances that may be lethal for animals. Tramadol dosage for animals for sufficient analgesia is 1-4 mg/kg. Overdosing can be fatal!

Pregnancy and breastfeeding Tramadol warning: please, bear in mind that Tramadol is extremely dangerous for the unborn baby! According to Food and Drug Administration classification it is a FDA pregnancy category C medicine that must not be taken by pregnant women unless the potential benefits of Tramadol outweigh the serious risks!

If the future mother uses the medication during pregnancy, Tramadol causes severe and even deadly side effects in newborn babies including neonatal withdrawal. Tramadol is known to pass into breast milk that is not you should not breastfeed your nursing baby if you follow the course of Tramadol therapy!

The common side effects of Tramadol include:

- nausea and vomiting, constipation, diarrhea, indigestion;
- sweating;
- drowsiness (less than with natural opioids);
- dizziness, fatigue;
- headache;
- dry mouth;
- seizures (very seldom in less than 1% of patients).

Please, bear in mind that almost 71% of all Tramadol patients experience some of the side effects listed above!

Tramadol withdrawal signs are also rather harsh. They are typical for patients who followed the course of Tramadol therapy for a long time taking high dosage of the drug. People who took Tramadol as general pain killer can experience uncontrollable nervous tremors and muscle contracture if they stopped the medication too abruptly. Anxiety and other similar sensations are also possible when you dropped Tramadol. Some patients develop respiratory depression common for opioid withdrawal. Some doctors underline negative effects of opioids on cognitive functioning and personality.

As you can see, Tramadol is a marvelous way out if you are in pain, but it can become addictive if you take in too long and in large amounts. If you keep asking yourself where can I buy Tramadol online, please, call your MD to find out the safest way of taking and stopping Tramadol before swallowing the first tablet. Think twice! Maybe you can do without any opioids at all?